New Insight into the Mechanism of Anaerobic Heme Degradation

Mitophagy: New Insight into the Cardiovascular Aging  

New Insight into the Relation between Adiponectin and Diabetes

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed...

New insight into the mechanism of mitochondrial cytochrome c function

We investigate functional role of the P76GTKMIFA83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c. According to this model, conformational rearrangements of the P76GTKMIFA83 loop fragment have a significant effect on conformational mobility of the heme. It is sugge...

New insight into the clinico-histomycological aspects of onychomycosis and a review of the literature

Background: Onychomycosis (OM) is the infection of nails caused by a variety of fungi. As systemic antifungal treatment is necessary in the majority of patients, appropriate diagnostic techniques are important to ensure a correct diagnosis and treatment. Objective: This study was carried out to evaluate the clinical, mycological, and histological aspects of onychomycosis in detail. Methods: A c...

New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors

  Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards FeIII-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. In this paper the results of a comparative study on the SLO inhibitory activities of the ...